RECOMBINANT LISTERIA VACCINE STRAINS AND METHODS OF PRODUCING THE SAME

• Main Authors: WALLECHA ANU, PETIT ROBERT
• Format: Patent
• Language: English; Korean
• Published: 20.12.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은 종양 또는 암에 대한 치료, 보호, 및 면역 반응 유도 방법을 제공하며, PrfA 기능을 부분적으로 복원하는 돌연변이체 PrfA 단백질을 암호화하는 핵산을 포함하는 재조합균주를 대상물에게 투여하는 단계를 포함한다. The present invention provides methods of treating, protecting against and inducing an immune response against a tumor or cancer, comprising the step of administering to a subject a recombinant Listeria strain. In one embodiment the present invention relates to a recombinant Listeria strain, said recombinant Listeria strain comprising a recombinant nucleic add, said nucleic add comprising a first open reading frame encoding a recombinant polypeptide comprising a first N-terminal fragment of an LLO protein fused to a heterologous antigen or fragment thereof, and wherein said recombinant nucleic add further comprises a second open reading frame encoding a mutant PrfA protein.