Tricyclic derivative compounds methods of preparing the same and pharmaceutical compositions comprising the same

The present invention relates to a novel tricyclic derivative compound, more specifically, to a tricyclic derivative compound having excellent PARP-1, tankyrase-1 or tankyrase-2 suppression activity, an optical isomer thereof, a racemic body thereof, or a pharmaceutically acceptable salt thereof. Th...

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Main Authors KIM, EUN SEON, KIM, JEONG MIN, CHUN, KWANG WOO, JOE, BO YOUNG, JANG, EUN SUNG, LEE, HAN CHANG, LEE, HYUN HO, OH, HYONG CHAN, PARK, JI SEON
Format Patent
LanguageEnglish
Korean
Published 19.12.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a novel tricyclic derivative compound, more specifically, to a tricyclic derivative compound having excellent PARP-1, tankyrase-1 or tankyrase-2 suppression activity, an optical isomer thereof, a racemic body thereof, or a pharmaceutically acceptable salt thereof. The tricyclic derivative compound, the optical isomer, the racemic body, or the pharmaceutically acceptable salt can be used for preventing or treating neuropathic pain, neurodegenerative diseases, cardiovascular diseases, neuralgia due to diabetes, inflammatory disease, osteoporosis, or cancer through suppression of PARP-1, tankyrase-1 or tankyrase-2. 본 발명은 신규한 트리사이클릭 유도체 화합물에 관한 것으로서, 보다 상세하게는 우수한 PARP-1. 탄키라제-1 또는 탄키라제-2 저해 활성을 갖는 트리사이클릭 유도체 화합물, 이의 광학이성질체, 이의 라세미체 또는 이의 약학적으로 허용가능한 염에 관한 것이다. 본 발명에 따른 트리사이클릭 유도체 화합물, 이의 광학이성질체, 이의 라세미체 또는 이의 약학적으로 허용 가능한 염은 PARP-1. 탄키라제-1 또는 탄키라제-2 저해 활성을 통하여 신경병리성 동통, 신경퇴화질환, 심혈관계 질환, 당뇨로 인한 신경병증, 염증성 질환, 골다공증 또는 암의 예방 또는 치료에 유용하게 사용될 수 있다.
Bibliography:Application Number: KR20160069199