5- -3- 5-SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF

• Main Authors: MITTAPALLI GOPI KUMAR, EASTMAN BRIAN, KC SUNIL KUMAR, WALLACE DAVID MARK, BOLLU VENKATAIAH, HOFILENA BRIAN JOSEPH, HOOD JOHN, MAK CHI CHING
• Format: Patent
• Language: English; Korean
• Published: 25.11.2016
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

다양한 질환들 및 병적 이상들을 치료하기 위한 인다졸 화합물들이 개시되어 있다. 더욱 구체적으로는, 본 출원은 Wnt 경로 신호전달의 활성화에 의해 특징되는 장애 (예컨대, 암, 비정상적 세포 증식, 혈관신생, 알츠하이머 병, 폐 질환, 섬유증 장애, 연골 (chondral) 결손, 및 골관절염), Wnt 경로 신호전달에 의해 매개된 세포 사건들의 조절, 및 DYRK1A의 과발현과 연결된 신경학적 병태/장애/질환들의 치료에 있어서 인다졸 화합물 또는 이의 유사체를 사용하는 것에 관한 것이다. Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.