Composition for prevention improvement or treatment of peripheral neuropathy comprising Lithospermi Radix extract as effective component

• Main Authors: KIM, NO SOO, BANG, OK SUN, PARK, JONG SHIK, KIM, YOUNG AH, LEE, YOU JIN, YI, JIN MU, KIM, JIN HEE, LIM, CHAE JUN, CHO, EUN SANG
• Format: Patent
• Language: English; Korean
• Published: 22.11.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a composition having lithospermi radix extract as an effective ingredient for preventing, alleviating or treating peripheral neuropathy, especially, the chemotherapy-induced peripheral neuropathy which is induced by an anticancer drug. More specifically, the lithospermi radix extract does not cause toxicity to normal cells, nor influence the effect of intrinsic cell toxicity of an anticancer drug in cancer cells of a human body while alleviating the growth of neurite, and highly reducing the sensitivity to nociceptive pain increasing in an animal model for peripheral neuropathy induced by the anticancer drug. Thus, the lithospermi radix extract can be used for an effective ingredient for a composition for preventing, alleviating or treating the peripheral neuropathy induced by the anticancer drug. 본 발명은 자근(Lithospermi Radix) 추출물을 유효성분으로 함유하는 말초신경병증(peripheral neuropathy), 특히 항암제로 유발된 말초신경병증(chemotherapy-induced peripheral neuropathy, CIPN) 예방, 개선 또는 치료용 조성물에 관한 것으로, 구체적으로 본 발명의 자근 추출물은 정상세포에 독성을 유발하지 않고, 인간 암세포주에서 항암제의 고유한 세포독성 효력에 영향을 주지 않으면서 동시에, 항암제에 의한 신경돌기 성장 억제를 완화하며, 항암제로 유발된 말초신경병증 동물모델에서 증가된 통증 자극에 대한 민감도를 효과적으로 감소시키는 것을 확인함으로써, 상기 자근 추출물은 항암제로 유발된 말초신경병증 예방, 개선 또는 치료용 조성물의 유효성분으로 유용하게 사용될 수 있다.