METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE

• Main Authors: HACKNEY JASON A, KEIR MARY, TEW GAIK WEI
• Format: Patent
• Language: English; Korean
• Published: 14.11.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

항-베타7 인테그린 서브유닛 항체를 포함한 인테그린 베타7 길항제에 대한 반응성을 예측하는 바이오마커, 및 상기 바이오마커의 사용 방법이 제공된다. 추가로, 위장 염증성 장애, 예컨대 궤양성 결장염 및 크론병을 포함한 염증성 장 질환의 치료 방법이 제공된다. 또한, 궤양성 결장염 및 크론병을 포함한 염증성 장 질환의 치료를 위한 상기 예측 바이오마커의 사용 방법이 제공된다. Biomarkers predictive of responsiveness to integrin beta7 antagonists, including anti-beta7 integrin subunit antibodies, and methods of using such biomarkers are provided. In addition, methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including ulcerative colitis and Crohn's disease are provided. Also provided are methods of using such predictive biomarkers for the treatment of inflammatory bowel diseases including ulcerative colitis and Crohn's disease.