N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS

• Main Authors: KALISH VINCENT JACOB, FROST LISA MARIE, TOSCANO JOHN P, BROOKFIELD FREDERICK ARTHUR, COHEN ANDREW D, COURTNEY STEPHEN MARTIN
• Format: Patent
• Language: English; Korean
• Published: 07.11.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 생리적 조건하에서 니트록실(HNO)를 공여하는 N-히드록시술폰아미드 유도체에 관한 것이며, 심부전 및 허혈/재관류 손상을 포함하는 니트록실 요법에 반응하는 질병 또는 질환의 발병 및/또는 진행을 치료 및/또는 예방하는데 유용하다. 신규의 N-히드록시술폰아미드 유도체는 생리적 조건하에서 조절된 속도에서 NHO를 방출하고, HNO 방출의 속도는 N-히드록시술폰아미드 유도체의 작용기의 성질 및 위치를 변경함으로써 조절된다. [색인어] 니트록실 도너, 히드록실술폰아미드, 심부전, 허혈, 재관류 The invention relates toN-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. NovelN-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on theN-hydroxysulfonamide derivatives.