BETA-HAIRPIN PEPTIDES HAVING ANTI-VIRAL PROPERTIES AGAINST THE DENGUE VIRUS

• Main Authors: HUERTA GALINDO VIVIAN, FALCON CAMA VIVIANA, MARTIN DUNN ALEJANDRO MIGUEL, VAZQUEZ CASTILLO MARIELA, SARRIA NUNEZ MONICA, YERO DIAZ ALEXIS, ALVAREZ PEREZ KAREN, REYES ACOSTA OSVALDO, GONZALEZ LOPEZ LUIS JAVIER, PUPO GOMEZ DIANNE, GARATEIX SUAREZ ROCIO, CHINEA SANTIAGO GLAY, GARAY PEREZ HILDA ELISA, GONZALEZ BLANCO SONIA, MARQUEZ PERERA GABRIEL JESUS, GUIROLA CRUZ OSMANY
• Format: Patent
• Language: English; Korean
• Published: 02.11.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 베타 헤어핀 구조의 형성에 최적화된, 구조적으로 제약된 합성 펩타이드를 개시한다. 상기 펩타이드는 뎅기열 바이러스(DENV) 감염을 억제하거나 약화시킬 수 있다. 본 발명은 또한 이 합성 펩타이드들을 함유하는 약학적 조성물을 개시하며, 이는 DENV-유발된 감염의 예방 및/또는 치료에 유용하다. 유사하게, 본 발명은 이 바이러스에 의해 유발된 감염을 치료하는 방법을 개시한다. The present invention discloses structurally constrained synthetic peptides that have been optimized for the formation of a beta hairpin structure. Said peptides are able to inhibit or attenuate Dengue virus (DENV) infections. The invention also discloses pharmaceutical compositions containing these synthetic peptides, which are useful for the prevention and/or treatment of DENV-caused infections. Likewise, the invention disclosed a method for treating infections caused by this virus.