ENZYMATIC PRODUCTION OF CYTOSINIC NUCLEOSIDE ANALOGUES

• Main Authors: DERONCELE THOMAS VICTOR M, MONTILLA AREVALO RAFAEL, PASCUAL GILABERT MARTA
• Format: Patent
• Language: English; Korean
• Published: 26.10.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to the enzymatic production of a cytosine nucleoside analog, and to a novel synthesizing method of a cytosine nucleoside analog by using nucleoside phosphorylase, especially by using pyrimidin nucleoside phosphorylase (PyNP) or purine nucleoside phosphorylase (PNP), and a mixture of the PyNP. 본 발명은 뉴클레오시드 가인산분해효소 (phosphorylase), 특히 피리미딘 뉴클레오시드 가인산분해효소 (Pyrimidin Nucleoside Phosphorylase, PyNP) 또는 퓨린 뉴클레오시드 가인산분해효소 (Purine Nucleoside Phosphorylase, PNP) 및 PyNP의 혼합물을 이용함으로써, 시토신 뉴클레오시드 유사체의 새로운 합성 방법에 관계한다.