RNA Compositions for gastrointestinal administration of RNA

• Main Authors: HASENPUSCH GUENTHER, UTZINGER MAXIMILIAN, RUDOLPH CARSTEN, PLANK CHRISTIAN, DOHMEN CHRISTIAN
• Format: Patent
• Language: English; Korean
• Published: 19.10.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은 폴리리보뉴클레오티드 (RNA) 및 양이온제를 포함하는 약학적 조성물로서, 위장관 (GI tract)에의 투여를 위한 고체 투약 형태로 제제화되는 약학적 조성물에 관한 것이다. 본 발명은 또한 RNA의 전신 전달을 위한 이러한 약학적 조성물의 용도 및 이러한 약학적 조성물을 GI 관에 투여하는 단계를 포함하는 RNA의 전신 전달을 위한 방법에 관한 것이다. 나아가, 본 발명은 키트에 관한 것이다. The present invention relates to a pharmaceutical composition comprising a polyribonucleotide (RNA) and a cationic agent, wherein said pharmaceutical composition is formulated as a solid dosage form for administration to the gastrointestinal (GI) tract. The present invention furthermore relates to the use of such a pharmaceutical composition for systemic delivery of RNA and to a method for systemic delivery of RNA to a subject comprising the step of administering such a pharmaceutical composition to the GI tract. Furthermore, the present invention relates to a kit.