134--2- - 134-thiadiazole-2-amine derivatives preparation method therof and pharmaceutical composition for use in preventing or treating Urotensin- receptor activity related diseases containing the same as an active ingredient

• Main Authors: LEE, JEONG HYUN, LIM, CHAE JO, SUH, JEE HEE, YI, KYU YANG, OH, KWANG SEOK, JANG, JU YOUNG, LEE, BYUNG HO
• Format: Patent
• Language: English; Korean
• Published: 12.10.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a 1, 3, 4-thiadiazole-2-amine derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating a urotensin-II receptor activity-associated disease. The 1, 3, 4-thiadiazole-2-amine derivative according to the present invention acts as an antagonist to the urotensin-II receptor, and thus the 1, 3, 4-thiadiazole-2-amine derivative may be usefully applied to treat or prevent a urotensin-II receptor activity-associated disease such as congestive heart failure, heart ischemia, myocardial infarction, cardiac hypertrophy, myofibrosis cordis, coronary artery disease, arteriosclerosis, hypertension, asthma, renal failure, diabetes, vascular inflammation, neurodegenerative disease, stroke, pain, depression, mental disease, and cancer. 본 발명은 1,3,4-싸이아다이아졸-2-아민 유도체, 이의 제조방법, 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 1,3,4-싸이아다이아졸-2-아민 유도체는 유로텐신-Ⅱ 수용체에 대한 길항제로 작용함으로써 울혈성 심부전, 심장 허혈, 심근경색, 심장 비대증, 심장 섬유증, 관상동맥 질환, 동맥경화증, 고혈압, 천식, 신부전, 당뇨병, 혈관염증, 신경퇴행성 질환, 뇌졸중, 통증, 우울증, 정신병, 암 등과 같은 유로텐신-Ⅱ 수용체 활성 관련 질환을 예방 또는 치료하는데 유용하게 사용할 수 있다.