(2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS

• Main Authors: VAN DE POEL AMANDA JANE, MACRITCHIE JAQUELINE ANNE, DOYLE KEVIN JAMES, LOENN HANS ROLAND, CONNOLLY STEPHEN, SWALLOW STEVEN, KARLSSON STAFFAN PO, AURELL CARL JOHAN, JONES GRAHAM PETER, PALMER NICHOLAS JOHN, PONTEN JOHN FRITIOF, WATSON DAVID WYN
• Format: Patent
• Language: English; Korean
• Published: 26.09.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 개시내용은 디펩티딜 펩티다제 1 (DPP1) 활성을 억제하는 특정 (2S)-N-[(1S)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드 화합물 (그의 제약상 허용되는 염 포함) (화학식 I), 호흡기 질환, 예컨대 천식 및 만성 폐쇄성 폐 질환 (COPD)을 포함한 임상 상태를 치료 및/또는 예방하는데 있어서의 그의 유용성, 요법에서의 그의 용도, 그를 함유하는 제약 조성물 및 이러한 화합물을 제조하는 방법에 관한 것이다. <화학식 I> The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.