1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

• Main Authors: JIANG HUALIANG, LUO RONGHUA, CHEN YING, WU BEILI, ZHENG YONGTANG, PENG PANFENG, LI JING, LI JIAN, XIE XIN, CHEN KAIXIAN, ZHOU YU, ZHANG HAONAN, LIU HONG, ZHU YA, YANG LIUMENG
• Format: Patent
• Language: English; Korean
• Published: 24.08.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 일반식(I)로 표시되는 1-(3-아미노프로필) 치환 고리형 아민계 화합물 및 이의 약학적으로 허용 가능한 염, 거울상 이성질체, 부분입체이성질체, 라세미체, 이들의 혼합물, 및 방향족 헤테로사이클릴 포름알데히드를 원료로 상기 1-(3-아미노프로필) 치환 고리형 아민계 화합물을 합성하는 방법을 제공한다. 상기 화합물은 HIV 감염을 치료하는 CCR5 길항제로 사용될 수 있다.I Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by formula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection.