HETEROARYL SUBSTITUTED NICOTINAMIDE COMPOUNDS

• Main Authors: DUNCIA JOHN V, KUMAR SREEKANTHA RATNA, SANTELLA JOSEPH B, WU HONG, ARUNACHALAM PIRAMANAYAGAM, SARKUNAM KANDHASAMY, PAIDI VENKATRAM REDDY, GARDNER DANIEL S, HYNES JOHN, NAIR SATHEESH KESAVAN, MURUGESAN NATESAN
• Format: Patent
• Language: English; Korean
• Published: 24.08.2016
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

화학식 I의 화합물 또는 그의 염이 개시되어 있다. <화학식 I>상기 식에서 HET는 피라졸릴, 인돌릴, 피롤로[2,3-b]피리디닐, 피롤로[2,3-d]피리미디닐, 피라졸로[3,4-b]피리디닐, 피라졸로[3,4-d]피리미디닐, 2,3-디히드로-1H-피롤로[2,3-b]피리디닐, 이미다조[4,5-b] 피리디닐, 및 퓨리닐로부터 선택된 헤테로아릴이고, 여기서 상기 헤테로아릴은 R및 R로 치환되고; R및 R는 본원에 정의된다. IRAK4의 조정제로서의 이러한 화합물을 사용하는 방법, 및 이러한 화합물을 포함하는 제약 조성물이 또한 개시되어 있다. 이들 화합물은 염증성 및 자가면역 질환을 치료, 예방, 또는 지연시키는데 유용하다. Disclosed are compounds of Formula (I) or salts thereof, wherein: HET is a heteroaryl selected from pyrazolyl, indolyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-d]pyrimidinyl, pyrazolo[3,4-b]pyridinyl, pyrazolo[3,4-d]pyrimidinyl, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridinyl, imidazo[4,5-b]pyridinyl, and purinyl, wherein said heteroaryl is substituted with Ra and Rb; and R1 and R2 are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases.