PIPERAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN

• Main Authors: GARCIA LOPEZ MONICA, ALMANSA ROSALES CARMEN, CUEVAS CORDOBES FELIX
• Format: Patent
• Language: English; Korean
• Published: 18.08.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 시그마(σ) 수용체, 및 μ-오피오이드 수용체 모두에 이중 약리학적 활성을 갖는 화합물, 보다 구체적으로 이러한 약리학적 활성을 갖는 피페라진 화합물, 이와 같은 화합물의 제조 공정, 이를 포함하는 약학적 조성물, 및 이의 치료 용도, 특히 통증 치료 용도에 관한 것이다. [화학식 (I)] The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to piperazine compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.