[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

• Main Authors: LIANG FANG, MATHISON CASEY JACOB NELSON, NAGLE ADVAIT SURESH, BIGGART AGNES, YEH VINCE, MOLTENI VALENTINA, SUPEK FRANTISEK
• Format: Patent
• Language: English; Korean
• Published: 05.08.2016
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 화학식 A의 화합물: 또는 그의 제약상 허용되는 염, 호변이성질체, 또는 입체이성질체를 제공하고, 여기서 변수는 본원에 정의된 바와 같다. <화학식 A>본 발명은 이러한 화합물을 포함하는 제약 조성물 및 기생충에 의해 유발되는 질환, 예컨대 리슈마니아증, 인간 아프리카 트리파노소마증 및 샤가스병의 병태 및/또는 증상을 치료, 예방, 억제, 개선 또는 근절시키기 위해 이러한 화합물을 사용하는 방법을 추가로 제공한다. The present invention provides compounds of Formula A:or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.