HUMANIZED ANTI-FACTOR D ANTIBODIES

• Main Authors: WU HERREN, FUNG SEK CHUNG, KELLEY ROBERT F, AN LING LING, LOWMAN HENRY B, SINGH SANJAYA
• Format: Patent
• Language: English; Korean
• Published: 03.08.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은 항-인간 D 인자 모노클로날 항체, 이의 핵산 및 아미노산 서열, 이러한 항체를 보유하는 세포 및 벡터, 및 과도한 또는 제어되지 않은 보체 활성화와 관련된 질환 및 장애의 치료를 위한 조성물 및 의약의 제조에서의 이들의 용도에 관한 것이다. 이러한 항체는 질환의 진단, 예방 및 치료에 유용하다. The invention relates to anti-Factor D antibodies and Factor D-binding fragments thereof, their nucleic acid sequences, the host cells and vectors that harbor these antibodies and Factor D-binding fragments, the method of making anti-Factor D antibodies and Factor D-binding fragments thereof, and the method of detecting Factor D. The invention also relates to compositions comprising the anti-Factor D antibodies or the Factor D-binding fragments thereof, their use in preparation of medicaments and treating disorders associated with excessive or uncontrolled complement activation.