ENHANCED PRODUCTION OF A RECOMBINANT POLYPEPTIDE BY OVEREXPRESSION OF MPC1

Provided are a recombinant cell in which overexpression of a mitochondrial pyruvate carrier (MPC) gene is induced; a composition used to produce a target polypeptide, which includes the recombinant cell and/or a recombinant vector including an MPC gene; and a production method of a target polypeptid...

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Main Authors PARK, EUN YOUNG, KIM, KYUNG EUN, SUH, HYE YOUNG, SUNG, HEE KYUNG, KIM, SUN KYU
Format Patent
LanguageEnglish
Korean
Published 18.07.2016
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Provided are a recombinant cell in which overexpression of a mitochondrial pyruvate carrier (MPC) gene is induced; a composition used to produce a target polypeptide, which includes the recombinant cell and/or a recombinant vector including an MPC gene; and a production method of a target polypeptide using the recombinant cell. The recombinant cell can be practically used to massively produce various therapeutic proteins. The production method of a target polypeptide comprises the following step: cultivating a recombinant cell in which overexpression of an MPC gene is induced. 미토콘드리아 피루베이트 수송체 (mitochondrial pyruvate carrier; MPC) 유전자의 과발현이 유도된 재조합 세포, 상기 재조합 세포 및/또는 MPC 유전자를 포함하는 재조합 벡터를 포함하는 목적 폴리펩타이드 생산용 조성물, 및 상기 재조합 세포를 이용하여 목적 폴리펩타이드의 생산 방법이 제공된다.
Bibliography:Application Number: KR20150002967