PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE

• Main Authors: KEANEY GREGG F, TIVITMAHAISOON PARCHAREE, LIU XIANG, WANG JOHN, GERARD BAUDOUIN, KOTAKE YOSHIHIKO, NAGAO SATOSHI, ARAI KENZO, KANADA SONOBE REGINA, KIRA KAZUNOBU, GEARHART NICHOLAS C, ZHENG GUO ZHU, MIYANO MASAYUKI, PRAJAPATI SUDEEP, MURAI NORIO
• Format: Patent
• Language: English; Korean
• Published: 08.07.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 신규 플라디에놀리드 피리딘 화합물, 이러한 화합물을 함유하는 제약 조성물, 및 상기 화합물을 치료제로서 사용하는 방법을 제공한다. 이들 화합물은 암, 특히 스플라이세오솜 및 그 안에서의 돌연변이를 표적으로 하는 작용제가 유용한 것으로 공지된 암의 치료에서 유용할 수 있다. The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.