METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T

• Main Authors: KREUTTER KEVIN D, VENKATESAN HARIHARAN, LEONARD KRISTI A, NISHIMURA RACHEL, BARBAY KENT, WOODS CRAIG R, EDWARDS JAMES P, XUE XIAOHUA, FOURIE ANNE, CUMMINGS MAXWELL D, URBANSKI MAUD, MAHAROOF UMAR, JONES WILLIAM MOORE, WANG AIHUA, KUMMER DAVID A, WOLIN RONALD L, GOLDBERG STEVEN
• Format: Patent
• Language: English; Korean
• Published: 15.06.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 화학식 I의 화합물을 포함한다.화학식 I 상기 식에서: R, R, R, R, R, R, R, R및 R은 본 명세서에서 정의된다. 본 발명은 또한 류머티스성 관절염 또는 건선인 증후군, 장애 또는 질환을 치료하거나 개선시키는 방법을 포함한다. 본 발명은 또한 적어도 하나의 제1항의 화합물의 치료적 유효량을 투여함으로써 포유동물에서 RORγt 활성을 조절하는 방법을 포함한다. The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.