SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS

• Main Authors: ESTRADA ANTHONY, YUEN PO WAI, HU BAIHUA, KOLESNIKOV ALEKSANDR, LIN XINGYU, DO STEVEN, SHORE DANIEL, CHEN HUIFEN, LYSSIKATOS JOSEPH P, CHU YANYAN, WANG LAN, WU GUOSHENG, VERMA VISHAL
• Format: Patent
• Language: English; Korean
• Published: 07.06.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 하기 화학식 I 또는 II의 화합물 및 이들의 염에 관한 것이다:. 본 발명은 또한, 화학식 I 또는 II의 화합물의 사용 방법뿐만 아니라, 상기 화합물을 함유하는 약학 조성물에 관한 것이다. 이들 화합물은, TRPA1 활성에 의해 매개되는 질환 또는 증상, 예컨대 통증의 치료에 유용할 수 있다. The invention is concerned with the compounds of formula I or II:and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.