AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

• Main Authors: PARMAR ALKA, WRIGHT SUSANNE, CANNING HANNAH, FARNABY WILLIAM, MACK STEPHEN, DAVENPORT RICHARD, BUFAM WILLIAM
• Format: Patent
• Language: English; Korean
• Published: 27.04.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 화학식 (I)의 화합물 및 약제학적으로 허용가능한 이의 염, 이의 제조방법, 이들을 함유하는 약제학적 조성물 및 치료에서의 이들의 용도에 관한 것이다:상기 화학식 (I)에서, R,X,m,R,Y,R,Z,n,R,A및 B는 명세서에서 정의된 바와 같다. The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, X, m, R2, Y, R3, Z, n, R4, A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.