FIVE-MEMBERED HETEROCYCLIC PYRIDINE COMPOUNDS AND PREPARATION METHOD AND USE THEREOF

• Main Authors: PENG XIA, WANG XIN, MA YUCHI, MA LANPING, CHEN DANQI, JI YINCHUN, GENG MEIYU, XIONG BING, CHEN YUELEI, DING JIAN, AI JING, MENG TAO, SHEN JINGKANG
• Format: Patent
• Language: English; Korean
• Published: 23.03.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 하기 일반식(X)로 표시된 5원 헤테로시클로 융합 피리딘계 화합물, 그의 약학적으로 허용가능한 염 또는 약학적으로 허용가능한 용매화물, 그의 제조방법, 상기 화합물을 포함하는 약물조성물, 및 이러한 화합물로 단백질 티로신 키나제 이상 관련 질병 및 종양을 예방 및/또는 치료하는 약물을 제조함에 있어서의 용도에 관한 것이다. This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of preducing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumours associated with abnormal protein tyrosine kinase.