METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLIC Γ-AMINO ACID DERIVATIVE

• Main Authors: KITAWAKI TAKAFUMI, KITAGAWA YUTAKA, IMAI MAKOTO, WAKAYAMA MASAKAZU, SAITO AYAKO, NUMAGAMI EIJI, NAKAJIMA TAKUMI, NAKAMURA YOSHITAKA, UKAI KAZUTOSHI, FURUYA YUKITO
• Format: Patent
• Language: English; Korean
• Published: 16.03.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

본 발명에서는, 광학 활성인 2 고리성 γ-아미노산 유도체를 고순도로 제공하는 것을 목적으로 한다. 그 해결 수단은, 일반식 (I) 및 일반식 (I') 를 갖는 화합물의 혼합물, 또는, 화합물 (I) 을 경유하여, 일반식 (VII) 을 갖는 화합물, 또는, 그 염을 제조하는 방법이다.[식 중, R및 R는 C1-6 알킬기 등을 나타내고, R은 시아노기 등을 나타낸다.] An object of the present invention is to provide an optically active bicyclic ³-amino acid derivative in a high purity. The object can be attained by a mixture of compounds represented by the general formulas (I) and (I'), or a method for producing a compound represented by the general formula (VII) or a salt thereof via the compound (I): wherein R 1 and R 2 each represent a C1-6 alkyl group or the like; and R 3 represents a cyano group or the like,