PYRIMIDINE DERIVATIVES HAVING ANTI-CANCER EFFECT, COMBINATION THERAPEUTIC EFFECT WITH RADIATION, AND ANTI-DIABETIC EFFECT, AND PPAR ACTIVITY, AND MEDICAL USE THEREOF

• Main Authors: PARK, JOUNG WHAN, LEE, KEE HO, HONG, SUNG HEE, HONG, DA WON
• Format: Patent
• Language: English; Korean
• Published: 11.03.2016
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLICBEVERAGES; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a pharmaceutical composition containing, as an active ingredient, a pyrimidine derivative which exhibits anticancer effects, radiation combination therapeutic effects, and diabetes treating effects. The pyrimidine derivatives of the present invention are ligands for peroxisome proliferator-activated receptor gamma (PPAR-γ), and exhibit anticancer activities against various cancers. In addition, the pyrimidine derivatives also have selective cytotoxicity against tumor cells, thereby functioning as an anticancer agent which can minimize side effects. Further, the pyrimidine derivatives can act as a therapeutic radiosensitizer involved in a cancer radiation therapy, and can also be used as a treatment agent for diabetes. 본 발명은 항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체를 유효성분으로 함유하는 약학조성물에 관한 것으로, 상기 피리미딘 유도체들은 PPAR-γ 리간드이면서, 각종 암에 대한 항암 활성을 가질 뿐만 아니라 암세포에 대해 선택적인 세포 독성을 가지므로 부작용을 최소화할 수 있는 항암제로서 작용할 수 있다. 또한, 암에 대한 방사선 치료에 있어서 방사선 치료 민감제로서 작용할 수 있으며, 당뇨병 치료제로서도 유용하게 사용될 수 있다.