TOPICAL AQUEOUS OPHTHALMIC COMPOSITIONS CONTAINING A 1H-INDOLE-1-CARBOXAMIDE DERIVATIVE AND USE THEREOF FOR TREATMENT OF OPHTHALMIC DISEASE

• Main Authors: POOR STEPHEN HEDRICK, ADAMS CHRISTOPHER MICHAEL, DODD STEPHANIE KAY, GHOSH MALAY
• Format: Patent
• Language: English; Korean
• Published: 12.02.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 1H-인돌-1-카복스아마이드를 포함하는 다회 용량 국소 안과용 조성물의 제공 및 안과용 질환의 치료를 위한 이의 용도에 관한 것이다. 더 구체적으로, 본 발명은 1H-인돌-1-카복스아마이드(예를 들어, N-(1-메틸-5-(트라이플루오로메틸)-1H-피라졸-3-일)-5-((6-((메틸아미노)메틸)피리미딘-4-일)옥시)-1H-인돌-1-카복스아마이드)를 포함하는 다회 용량 수성 안과용 조성물(예를 들어, 용액, 현탁액, 에멀션 등) 및 눈의 후방에서의 안과용 질환, 예컨대 연령 관련 황반변성(AMD)의 치료를 위한 이의 용도에 관한 것이다. The present invention is directed to the provision of a multi-dose topical ophthalmic composition containing a 1H-indole-1-carboxamide and use thereof for treatment of ophthalmic disease. More specifically the present invention is directed to a multi-dose aqueous ophthalmic composition (e.g., a solution, a suspension, an emulsion or the like) containing a 1H-indole-1-carboxamide (e.g., N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide) and use thereof for treatment of an ophthalmic disease at the back of the eye such as age related macular degeneration (AMD).