CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME

• Main Authors: GAO WEI, LEE, SANG WOOK, SUH, JOO WON, KIM, JONG WOO, PARK, SANG JIN, FRIESEN BRENT, JIN YING YU, LEE, JI EAN, RODRIGUEZ BRASCO MARIA FLORENCIA, YOON, TAE MI, CHOI, JONG KEUN, LANKIN DAVID, JAKI BIRGIT, LEE, IN AE, MCALPINE JAMES, KIM, JIN YONG, FRANZBLAU SCOTT, CHO SANGHYUN, PAULI GUIDO, NAPOLITANO JOSE
• Format: Patent
• Language: English; Korean
• Published: 28.12.2015
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 노노무라에아 종 MJM5123(Nonomuraea sp. MJM5123)으로부터 새로운 항결핵 고리형 펩티드(anti-TB cyclic peptides), 항결핵 펩티드 생산을 위한 프로세스 및 이를 포함하는 마이코박테리아 감염의 치료 및 예방을 위한 약학적 조성물에 관한 것이다. 본 발명의 조성물은 MDR 및 XDR을 포함하는 복제/비복제 M. 결핵에 대항하여 매우 활동적이므로, 결핵 치료제로서 효과적으로 사용될 수 있다. The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.