USE OF REV-ERBα FOR TREATING AFFECTIVE AND ADDICTIVE DISORDERS
The present invention relates to a correlation between a dopamine synthesis system in a midbrain and a biological clock involving in a mechanism of regulating circadian rhythm. According to the present invention, by using a REV-ERBα protein for biological clock and a gene encoding the protein, it is...
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Format | Patent |
Language | English Korean |
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19.11.2015
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Abstract | The present invention relates to a correlation between a dopamine synthesis system in a midbrain and a biological clock involving in a mechanism of regulating circadian rhythm. According to the present invention, by using a REV-ERBα protein for biological clock and a gene encoding the protein, it is possible to screen novel drug candidate materials for treating and/or preventing cerebropathy caused by an abnormal regulation of the dopamine system. In addition, the present invention may provide a pharmaceutical composition having effects of preventing and/or treating cerebropathy caused by the abnormal dopamine system regulation, by inhibiting REV-ERBα protein which is a nuclear receptor and the gene encoding the protein.
본 발명은 일주기적 조절 기작에 관여하는 생체시계 유전자와 중뇌 도파민 합성 시스템과의 관련성에 관한 것이다. 본 발명에 따르면, 생체시계 단백질인 REV-ERBα 단백질 및 이를 코딩하는 유전자를 이용하여 도파민 시스템 조절이상에서 기인하는 뇌질환을 예방 및/또는 치료하기 위한 신규한 약물후보물질을 스크리닝할 수 있다. 또한, 본 발명은 핵수용체인 REV-ERBα 단백질 및 이를 코딩하는 유전자를 억제하여, 도파민 시스템 조절이상에서 기인하는 뇌질환의 예방 및/또는 치료에 효과가 있는 약학조성물을 제공할 수 있다. |
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AbstractList | The present invention relates to a correlation between a dopamine synthesis system in a midbrain and a biological clock involving in a mechanism of regulating circadian rhythm. According to the present invention, by using a REV-ERBα protein for biological clock and a gene encoding the protein, it is possible to screen novel drug candidate materials for treating and/or preventing cerebropathy caused by an abnormal regulation of the dopamine system. In addition, the present invention may provide a pharmaceutical composition having effects of preventing and/or treating cerebropathy caused by the abnormal dopamine system regulation, by inhibiting REV-ERBα protein which is a nuclear receptor and the gene encoding the protein.
본 발명은 일주기적 조절 기작에 관여하는 생체시계 유전자와 중뇌 도파민 합성 시스템과의 관련성에 관한 것이다. 본 발명에 따르면, 생체시계 단백질인 REV-ERBα 단백질 및 이를 코딩하는 유전자를 이용하여 도파민 시스템 조절이상에서 기인하는 뇌질환을 예방 및/또는 치료하기 위한 신규한 약물후보물질을 스크리닝할 수 있다. 또한, 본 발명은 핵수용체인 REV-ERBα 단백질 및 이를 코딩하는 유전자를 억제하여, 도파민 시스템 조절이상에서 기인하는 뇌질환의 예방 및/또는 치료에 효과가 있는 약학조성물을 제공할 수 있다. |
Author | KIM, KYUNG JIN SON, GI HOON CHUNG, SOO YOUNG |
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DocumentTitleAlternate | 정서장애 및 중독질환 치료를 위한 REV-ERBα 유전자의 용도 |
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Snippet | The present invention relates to a correlation between a dopamine synthesis system in a midbrain and a biological clock involving in a mechanism of regulating... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
Title | USE OF REV-ERBα FOR TREATING AFFECTIVE AND ADDICTIVE DISORDERS |
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