USE OF REV-ERBα FOR TREATING AFFECTIVE AND ADDICTIVE DISORDERS

• Main Authors: KIM, KYUNG JIN, SON, GI HOON, CHUNG, SOO YOUNG
• Format: Patent
• Language: English; Korean
• Published: 19.11.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a correlation between a dopamine synthesis system in a midbrain and a biological clock involving in a mechanism of regulating circadian rhythm. According to the present invention, by using a REV-ERBα protein for biological clock and a gene encoding the protein, it is possible to screen novel drug candidate materials for treating and/or preventing cerebropathy caused by an abnormal regulation of the dopamine system. In addition, the present invention may provide a pharmaceutical composition having effects of preventing and/or treating cerebropathy caused by the abnormal dopamine system regulation, by inhibiting REV-ERBα protein which is a nuclear receptor and the gene encoding the protein. 본 발명은 일주기적 조절 기작에 관여하는 생체시계 유전자와 중뇌 도파민 합성 시스템과의 관련성에 관한 것이다.　본 발명에 따르면, 생체시계 단백질인　 REV-ERBα 단백질 및 이를 코딩하는 유전자를 이용하여 도파민 시스템 조절이상에서 기인하는 뇌질환을 예방 및/또는 치료하기 위한 신규한 약물후보물질을 스크리닝할 수 있다.　또한, 본 발명은 핵수용체인 REV-ERBα 단백질 및 이를 코딩하는 유전자를 억제하여, 도파민 시스템 조절이상에서 기인하는 뇌질환의 예방 및/또는 치료에 효과가 있는 약학조성물을 제공할 수 있다.