GAMMA-DIKETONES AS WNT/BETA-CATENIN SIGNALING PATHWAY ACTIVATORS

• Main Authors: BARROGA CHARLENE F, KC SUNIL KUMAR, WALLACE DAVID MARK, HOOD JOHN
• Format: Patent
• Language: English; Korean
• Published: 26.10.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 Wnt/β-카테닌 신호전달을 활성화하고 따라서 신호 전달에 관련된 질병, 가령 골다공증 및 골관절증; 골형성부전증, 골 결함, 골절, 치주 질환, 귀경화증, 상처 치유, 두개안면 결함, 온콜리틱(oncolytic) 골 질환, 외상성 뇌손상 또는 척추 손상, 파킨슨병, 뇌졸중, 허혈성 뇌 질환, 뇌전증, 알츠하이머병, 우울증, 조울증, 정신분열증을 비롯한, 중추신경계의 분화 및 발달과 관련된 뇌 위축/신경 질환; 와우 모세포 손실과 같은 귀 질환; 안 질환, 가령 연령 관련 황반 변성, 당뇨병성 황반부종 또는 망막 색소변성증 그리고 줄기세포의 분화 및 성장과 관련된 질환, 가령 탈모, 조혈작용 관련 질환 그리고 조직 재생 관련 질환을 치료하거나 예방하는 γ-디케톤 또는 이의 유사체를 제공한다. The present disclosure provides ³-diketones or analogs thereof, that activate Wnt/²-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.