FLUORINATED INTEGRIN ANTAGONISTS

• Main Authors: EDWARDS D. SCOTT, ASKEW BEN C, HEIDEBRECHT RICHARD W, DUGGAN MARK E, FURUYA TAKERU
• Format: Patent
• Language: English; Korean
• Published: 14.10.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 화학식 I의 플루오르화 화합물 및 당해 화합물의 합성 방법에 관한 것이다. 본 발명은 또한 본 발명의 플루오르화 화합물을 함유하는 약제학적 조성물, 및 당해 화합물 및 약제학적 조성물을 이의 필요가 있는 대상에게 투여함으로써 황반 변성, 당뇨병성 망막증(DR), 황반 부종, 당뇨병성 황반 부종(DME), 및 망막 정맥 폐쇄(RVO) 후 황반 부종을 치료하는 방법에 관한 것이다. The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.