PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF STROKE AND SYSTEMIC EMBOLISM

The present invention relates to a prodrug useful for treating or preventing a stroke and systemic embolism and suitable for being effectively used in the oral delivery of dabigatran, and to a compound represented by chemical formula 1, a pharmaceutically acceptable salt thereof, and a hydrate there...

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Main Authors LIM, HONG GYU, KIM, HYUN JUNG, SHIM, HYUN JOO, LEE, JI HYE, LEE, DAE YOUNG, CHA, DAE WON, LIM, JOONG IN, KWAK, WOO YOUNG, SON, BYOUNG HWA, CHOI, JUN HO, RYU, CHAE LIM
Format Patent
LanguageEnglish
Korean
Published 21.09.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a prodrug useful for treating or preventing a stroke and systemic embolism and suitable for being effectively used in the oral delivery of dabigatran, and to a compound represented by chemical formula 1, a pharmaceutically acceptable salt thereof, and a hydrate thereof or a solvate thereof. The compound represented by the chemical formula 1, the pharmaceutically acceptable salt thereof, and the hydrate thereof or the solvate thereof are useful for treating or preventing a stroke and systemic embolism, and is suitable for being effectively used in oral delivery since the absorption rate, that is, bioavailability of dabigatran is improved.
Bibliography:Application Number: KR20150032656