INHIBITORS OF BRUTON'S TYROSINE KINASE

• Main Authors: LOPEZ TAPIA FRANCISCO JAVIER, LAINE DRAMANE IBRAHIM, STEVENSON CHRISTOPHER, IYER RAMAN MAHADEVAN, PHILLIPS JONATHAN E
• Format: Patent
• Language: English; Korean
• Published: 02.07.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 본원에 기술된 바와 같은 Btk 억제제 화합물 6-tert-부틸-8-플루오로-2-{3-하이드록시메틸-4-[1-메틸-5-(1'-메틸-1',2',3',4',5',6'-헥사하이드로-[3,4']바이피리딘일-6-일아미노)-6-옥소-1,6-다이하이드로-피리다진-3-일]-피리딘-2-일}-2H-프탈라진-1-온, 2-(2-{3-[5-(5-아제티딘-1-일메틸-1-메틸-1H-피라졸-3-일아미노)-1-메틸-6-옥소-1,6-다이하이드로-피리다진-3-일]-2-하이드록시메틸-페닐}-8-플루오로-1-옥소-1,2-다이하이드로-이소퀴놀린-6-일)-2-메틸-프로피오니트릴 및 6-tert-부틸-2-[2-하이드록시메틸-3-(5-{5-[(2-메톡시-에틸아미노)-메틸]-피리딘-2-일아미노}-6-옥소-1,6-다이하이드로-피리딘-3-일)-페닐]-3,4-다이하이드로-2H-이소퀴놀린-1-온, 이들의 제형, 및 천식의 치료 방법에 관한 것이다. This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3-hydroxymethyl-4-[1-methyl-5-(1′-methyl-1′,2′,3′,4′,5′,6′-hexahydro-[3,4′]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2-hydroxy methyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2-ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.