ALKYNYL HETEROAROMATIC RING COMPOUND AND APPLICATION THEREOF

• Main Authors: XU XIN, CHEN HONGYAN, CHEN HONGBIN, LIU YANG, ZHANG WENPING, WANG YONG, ZHAO LIWEN, GAO YIPING, ZHANG CANG, BI SHENG
• Format: Patent
• Language: English; Korean
• Published: 17.06.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 알키닐 헤테로방향족 고리(alkynyl heteroaromatic ring) 구조를 가진 화합물 또는 상기 약학상 수용 가능한 소금, 입체이성체, N-옥사이드(N-oxide), 용매화물 또는 프로드러그(prodrug) 및 상기 화합물을 함유한 의약조성물, 및 상기 화합물 또는 조성물을 약물 제조에 응용하는 것에 관한 것이다. 상기 화합물은 비교적 우수한 항종양 활성을 가지고 있다. The present invention belongs to the field of pharmaceutical chemistry, and specifically relates to compounds having an alkynyl heteroaromatic ring structure and pharmaceutically acceptable salts, stereoisomers, N-oxides, solvates, or prodrugs thereof, and pharmaceutical compositions comprising these compounds, as well as uses of these compounds and compositions in the manufacture of a medicament. The compounds of the present invention and the pharmaceutically acceptable salts, stereoisomers, N-oxides, solvates or prodrugs thereof and the pharmaceutical compositions comprising the compounds have better anti-tumor activity.