PHARMACEUTICAL COMBINATION COMPRISING SUSTAINED-RELEASE TYPE METFORMIN AND IMMEDIATE-RELEASE TYPE HMG-COA REDUCTASE INHIBITOR

• Main Authors: KIM, YU JEONG, OH, TACK OON, LEE, JI EUN, PARK, YOUNG JOON, YOON, SEOK KEE, PARK, JUN HONG, CHO, TAE KEUN, KANG, KWI MAN
• Format: Patent
• Language: English; Korean
• Published: 29.05.2015
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a complex formulation containing metformin used in the insulin-free treatment of diabetes and an HMG-CoA reductase inhibitor used in the treatment of dyslipidemia. The present invention provides a complex formulation and a method for preparing the complex formulation, wherein the complex formulation contains metformin and an HMG-CoA reductase inhibitor, and has effectively improved stability by securing the stable release of respective active ingredients and blocking physical and chemical reactions between the active ingredients. 본 발명은 인슐린 비의존성 당뇨병 치료 등에 사용되는 메트포르민과 이상지질혈증 치료 등에 사용되는 HMG-CoA 환원효소 억제제를 포함하는 복합제제에 관한 것으로, 메트포르민 및 HMG-CoA 환원효소 억제제를 포함하고, 각 유효성분의 안정적인 방출을 확보하는 동시에 유효성분 간의 물리, 화학적인 반응을 차단시켜 안정성을 효과적으로 개선한 복합제제를 제공하기 위한 것이다.