THE PREPARING METHOD OF CORE-SHELL STRUCTURED SCAFFOLD FOR HARD TISSUE REGENERATION AND THE SCAFFOLD FOR HARD TISSUE REGENERATION THEREBY

• Main Authors: YUN, HUI SUK, RAJA NAREN, LEE, JONG MAN
• Format: Patent
• Language: English; Korean
• Published: 20.05.2015
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The present invention relates to a method for manufacturing a support for regenerating core-shell structured hard tissue and a support for regenerating core-shell structured hard tissue manufactured thereby, wherein the support may further comprise bio-functional materials, such as cells, in a core-shell structure. The method for manufacturing a support for regenerating core-shell structured hard tissue according to the present invention has an effect of manufacturing a support for regenerating core-shell structured hard tissue by a method by which a three-dimensional structure is prepared by a layer manufacturing method through an extrusion container having a double nozzle. In addition, the support can be manufactured at room temperatures, thereby having an effect of containing cells or various bio-functional materials. Further, the support for regenerating core-shell structured hard tissue has a similar constitution to a bone component and thus has higher mechanical properties, and has an effect in which the cells or various bio-functional materials are uniformly distributed throughout the entire three-dimensional structure. 본 발명은 코어-쉘 구조 경조직 재생용 지지체의 제조방법 및 이를 통해 제조된 코어-쉘 구조 경조직 재생용 지지체에 관한 것으로, 코어-쉘 구조에 세포 등과 같은 생체기능성 물질을 더 포함할 수 있는 것을 특징으로 한다. 본 발명에 따른 코어-쉘 구조 경조직 재생용 지지체의 제조방법은 이중노즐을 가지는 압출 용기를 통해 적층조형법으로 3 차원 구조체를 제조하는 방법으로 코어-쉘 구조의 경조직 재생용 지지체를 제조할 수 있는 효과가 있다. 또한, 상온에서 제조할 수 있기 때문에 세포 또는 각종 생체기능성 물질을 포함시킬 수 있는 효과가 있다. 나아가, 본 발명에 따른 코어-쉘 구조 경조직 재생용 지지체는 골 성분과 유사한 구성으로 기계적 물성이 높으며, 3 차원 구조체 전반에 걸쳐 세포 또는 생체기능성 물질이 균일하게 분포되어 있는 효과가 있다.