ETHYNYL DERIVATIVES AS MGLUR5 ALLOSTERIC MODULATORS

The present invention relates to ethynyl derivatives of formula I wherein U, V, Y, R1, R2, R2′, R3, R3′ and R8 are described herein. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

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Bibliographic Details
Main Authors RICCI ANTONIO, RUEHER DANIEL, STADLER HEINZ, LINDEMANN LOTHAR, JAESCHKE GEORG, VIEIRA ERIC
Format Patent
LanguageEnglish
Korean
Published 24.06.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to ethynyl derivatives of formula I wherein U, V, Y, R1, R2, R2′, R3, R3′ and R8 are described herein. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
Bibliography:Application Number: KR20147011355