HYPOXIA-RESPONSIVE NANOPARTICLE FOR THERAPY AND IMAGING OF HYPOXIA-INVOLVING DISEASES

• Main Author: PARK, JAE HYUNG
• Format: Patent
• Language: English; Korean
• Published: 21.05.2014
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT THEREOF; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS,MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES ASDISCRETE UNITS; NANOTECHNOLOGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION; TECHNICAL SUBJECTS COVERED BY FORMER USPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING

The present invention relates to an amphiphilic polymer of which properties and a structure can be changed under a hypoxic condition, and to nanoparticles formed by self-assembly of the amphiphilic polymer. The hypoxia-sensitive nanoparticles according to the present invention selectively release a treating agent under a hypoxic condition and thus can be applied to a selective diagnosis and a selective treatment of diseases accompanied by hypoxia. Especially, with respect to the treatment of cancer, the hypoxia-sensitive nanoparticles can release the treating agent only in response to a targeted tumor and thus can minimize side effects and maximizes treatment effects.