PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF
The present invention concerns therapeutic agents that, in association with stimulation of PDGFR±-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. In particular, fra...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English Korean |
Published |
25.03.2014
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention concerns therapeutic agents that, in association with stimulation of PDGFR±-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. In particular, fragments of High mobility Group Box 1 (HMGB1 or amphoterin) which stimulate PDGFRalpha-positive cells and promote their mobilization into blood and accumulation in a damaged tissue. Peptide fragments of HMGB1 were identified with migration-promoting activity on PDGFR-alpha-positive bone marrow mesenchymal stem cell line (MSC-1) and skin fibroblasts. |
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Bibliography: | Application Number: KR20137031356 |