BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS

Disclosed are compounds of Formula (I) or prodrugs thereof; wherein: R1 is -CH2CF3 or -CH2CH2CF3; R2 is -CH2CF3, -CH2CH2CF3, or -CH2CH2CH2CF3; R3 is H or -CH3; each Ra is independently F, Cl, -CN, -OCH3, and/or -NHCH2CH2OCH3; and z is zero, 1, or 2. Also disclosed are methods of using such compounds...

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Bibliographic Details
Main Authors GAVAI ASHVINIKUMAR, KIM SOONG HOON, LEE FRANCIS, QUESNELLE CLAUDE
Format Patent
LanguageEnglish
Korean
Published 07.03.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are compounds of Formula (I) or prodrugs thereof; wherein: R1 is -CH2CF3 or -CH2CH2CF3; R2 is -CH2CF3, -CH2CH2CF3, or -CH2CH2CH2CF3; R3 is H or -CH3; each Ra is independently F, Cl, -CN, -OCH3, and/or -NHCH2CH2OCH3; and z is zero, 1, or 2. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Bibliography:Application Number: KR20137027347