CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH?? RECEPTOR MODULATORS

The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and...

Full description

Saved in:
Bibliographic Details
Main Authors HUANG YING, BUTCHER JOHN W, DONG LI, PALANI ANANDAN, ASLANIAN ROBERT G, SILIPHAIVANH PHIENG, SHAO NING, ZHOU WEI, CLOSE JOSHUA T, BRUBAKER JASON, PETERSON SCOTT L, MACCOSS RACHEL NICOLA, ZHANG HONGJUN, MCCORMICK KEVIN D, HUANG XIANHAI, JUNG JOON O, BIJU PURAKKATTLE JOHNY, MARTINEZ MICHELLE
Format Patent
LanguageEnglish
Korean
Published 04.03.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
Bibliography:Application Number: KR20147000987