PREPARATION METHOD FOR NEW TAUTOMYCETIN ANALOGUE WITH STREPTOMYCES SP. CK4412 STRAIN AND IMMUNOSUPPRESSANT COMPRISING TAUTOMYCETIN ANALOGUE AS ACTIVE INGREDIENT

The present invention relates to a production method of a new tautomycetin derivative using Streptomyces sp. CK4412 strains and an immunosuppressant including thereof as an active ingredient, which provides a production method of 5-deoxy tautomycetin producing tmcR genes from chromosome DNA of the S...

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Bibliographic Details
Main Authors CHOI, SI SUN, KIM, DONG JU, NAH, JI HYE, SHIN, HWA SUNG, KIM, EUNG SOO, DAVID H. SHERMAN
Format Patent
LanguageEnglish
Korean
Published 05.02.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a production method of a new tautomycetin derivative using Streptomyces sp. CK4412 strains and an immunosuppressant including thereof as an active ingredient, which provides a production method of 5-deoxy tautomycetin producing tmcR genes from chromosome DNA of the Streptomyces sp. CK4412 strains. Using the 5-deoxy tautomycetin, the immunosuppression ability of the immunosuppressant is improved and the toxicity of the immunosuppressant is reduced compare to existing tautomycetin.
Bibliography:Application Number: KR20120077769