ANTI-RESORPTIVE AND BONE BUILDING DIETARY SUPPLEMENTS AND METHODS OF USE

• Main Authors: KREMPIN DAVID W, DA COSTA SILVIA R, REBHUN JOHN F, FAST DAVID J, WILKINS LEON M, ROH SCHMIDT HAERI, MURRAY MARY A, LIN YUMEI, RANA JATINDER, GELLENBECK KEVIN W
• Format: Patent
• Language: English; Korean
• Published: 29.01.2014
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

Disclosed herein are dietary supplement compositions, regimens and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Siberian ginseng, Sophora japonica , and licorice, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of green tea, grape seed, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.