ANTIBODY-DRUG CONJUGATE FORMED THROUGH TRANSGLUTAMINASE AND USE THEREOF

The present invention relates to a method of producing an antibody-medicine corporate body comprising a step of making mutated antibody including glutamine and medicine including free amine group react under the existence of transglutaminase, to an antibody-medicine corporate body produced thereby,...

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Bibliographic Details
Main Authors MOON, KYUNG DUK, KO, MIN JI, PARK, SANG KYUNG, KIM, YOUNG MIN, SONG, DAE HAE
Format Patent
LanguageEnglish
Korean
Published 04.12.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a method of producing an antibody-medicine corporate body comprising a step of making mutated antibody including glutamine and medicine including free amine group react under the existence of transglutaminase, to an antibody-medicine corporate body produced thereby, to an antibody-medicine corporate body in which medicine including mutated antibody and free amine group connected by isopeptide bond, to a composition for treating cancer including the antibody-medicine corporate body, to a method for treating cancer by using the antibody-medicine corporate body, and to a mutated body to which peptide including glutamine and antibody are connected.
Bibliography:Application Number: KR20120154955