FLUORINATION PROCESS OF ANILIDE DERIVATIVES AND BENZOTHIAZOLE FLUORINATE DERIVATIVES AS IN VIVO IMAGING AGENTS

The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10a...

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Main Authors GIBSON ALEXANDER MARK, KARIMI FARHAD, BOUVET DENIS RAYMOND CHRISTOPHE, LANGSTROM BENGT, JONES CLARE LOUISE, FAIRWAY STEVEN MICHAEL, NAIRNE ROBERT JAMES, WILLIAMS LORENZO, LASBISTES NICOLAS, STOREY ANTHONY EAMON
Format Patent
LanguageEnglish
Korean
Published 16.10.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEAR ENGINEERING
NUCLEAR PHYSICS
NUCLEAR REACTORS
ORGANIC CHEMISTRY
PHYSICS
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Summary:The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, -(CH2CH2O)q-CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
Bibliography:Application Number: KR20137025584