NOVEL MICROORGANISMS HAVING IMPROVED PRODUCTIVITY OF RAPAMYCIN

PURPOSE: A novel microorganism strain is provided to remarkably increase rapamycin productivity compared with a conventional rapamycin-producing strain. CONSTITUTION: A microorganism strain contains inactivated rap Y gene, inactivated rapS gene, or inactivated rapS gene and inactivated rapY gene and...

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Bibliographic Details
Main Authors KANG, TAE WON, YOO, YOUNG JI, LEE, YOO WON, YOON, YEO JOON, YU, SEONG SEON
Format Patent
LanguageEnglish
Korean
Published 01.10.2013
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PURPOSE: A novel microorganism strain is provided to remarkably increase rapamycin productivity compared with a conventional rapamycin-producing strain. CONSTITUTION: A microorganism strain contains inactivated rap Y gene, inactivated rapS gene, or inactivated rapS gene and inactivated rapY gene and has rapamycin productivity. The strain is Streptomyces hygroscopicus. rapY gene or rapS gene is inactivated by substitution, deletion, or insertion.
Bibliography:Application Number: KR20120028776