METHOD FOR IN VIVO TARGETING OF NANOPARTICLES VIA BIOORTHOGONAL COPPER-FREE CLICK CHEMISTRY

PURPOSE: A method for in vivo targeting of nanoparticles by bioorthogonal copper-free click chemistry is provided to control the in vivo distribution of nanoparticles and to remarkably increase the accumulation in vivo of the nanoparticle in a target part. CONSTITUTION: A method for in vivo targetin...

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Bibliographic Details
Main Authors KIM, KWANG MEYUNG, KOO, HEE BEOM, CHOI, KUI WON, KWON, ICK CHAN, LEE, SANG MIN, YOUN, IN CHAN
Format Patent
LanguageEnglish
Korean
Published 30.09.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:PURPOSE: A method for in vivo targeting of nanoparticles by bioorthogonal copper-free click chemistry is provided to control the in vivo distribution of nanoparticles and to remarkably increase the accumulation in vivo of the nanoparticle in a target part. CONSTITUTION: A method for in vivo targeting of nanoparticles comprises a step of putting in the precursor which can control metabolism in vivo and has a first bioorthogonal functional group; and a step of putting a nanoparticle which is attached with a second bioorthogonal functional group bioorthogonally reactable with the first bioorthogonal functional group. The metabolism control is a sugar chain control. The precursor is a compound selected from chemical formulas 1 to 3.
Bibliography:Application Number: KR20120028370