SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED IN LEFT VENTRICULAR HYPERTROPHY AND USE THEREOF

• Main Authors: SHIN, DONG JIK, HONG, KYUNG WON, LEE, SANG HAK, JANG, YANG SOO, OH, BERM SEOK
• Format: Patent
• Language: English; Korean
• Published: 25.09.2013
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

PURPOSE: A single nucleotide polymorphism (SNP) related to left ventricular hypertrophy is provided to predict cardiovascular diseases through diagnosis of left ventricular hypertrophy, thereby enabling genetic in vitro diagnosis on vascular diseases. CONSTITUTION: A kit for diagnosing left ventricular hypertrophy contains a primer or a probe which specifically binds to 10-100 continuous nucleotide sequences with one or more SNPs. The SNPs are selected among: 301th base of sequence number 1 and 201th base of sequence number 3 in ryanodine receptor 1 (RYR1) gene; 201th base of sequence number 4 in dopamine receptor D1 (DRD1) gene; 256th base of sequence number 5 in toll-interleukin 1 receptor domain containing adaptorprotein (TTRAP) gene; 201th base of sequence number 6, 502th base of sequence number 7, 301th base of sequence number 8, and 960th of sequence number 9 in family with sequence similarity 135, member B (FAM135B) gene; 301th base of sequence number 10 in UDP-N-acetylalpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4 (GALNTL4) gene; 251th base of sequence number 11 in dynein, cytoplasmic 2, heavy chain 1 (DYNC2H1) gene; and 401th base of sequence number 12 in DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) gene.