COMPOSITION FOR SUPPRESSION OF CANCER METASTASIS CONTAINING NECROX

PURPOSE: A composition containing NecroX for suppressing cancer metastasis is provided to suppress the activation of Cdc42 or Rac1 or to reduce intracellular calcium concentration, thereby being used as a pharmaceutical composition or a food composition for suppressing cancer metastasis. CONSTITUTIO...

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Main Authors PARK, JIN HEE, SEO, SU KIL, HAN, JIN, YU, BYENG CHUL, KIM, HYOUNG KYU, PARK, SAE GWANG, HONG, JUN HYUK, PARK, SUNG JAE, URM, SANG HWA, CHOI, IL WHAN
Format Patent
LanguageEnglish
Korean
Published 08.08.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE: A composition containing NecroX for suppressing cancer metastasis is provided to suppress the activation of Cdc42 or Rac1 or to reduce intracellular calcium concentration, thereby being used as a pharmaceutical composition or a food composition for suppressing cancer metastasis. CONSTITUTION: A composition for suppressing cancer metastasis contains NecroX which is selected among NecroX-1, NecroX-2, NecroX-5, NecroX-7, and NecroX-18. NecroX suppresses cancer metastasis by reducing cancer infiltration into tissues. The cancer infiltration into tissues is reduced by suppressing the expression of Rac1 and Cdc42 or reducing intracellular calcium concentration.
Bibliography:Application Number: KR20120115122