DIHYDROBENZOXATHIAZEPINE DERIVATIVES, PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS AND USE AS AMPA RECEPTOR MODULATORS

• Main Authors: CORDI ALEXIS, LESTAGE PIERRE, DESOS PATRICE, DANOBER. LAURENCE
• Format: Patent
• Language: English; Korean
• Published: 24.05.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Phenoxy-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine-dioxide compounds (I) and their enantiomers and diastereoisomers, and addition salts with an acid or a base, are new. Phenoxy-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine-dioxide compounds of formula (I) and their enantiomers and diastereoisomers, and addition salts with an acid or a base, are new. R1 = H, CN, 1-6C alkoxycarbonyl group, 1-6C alkylsulfonylamino1-6C alkyl group or N-hydroxy carboximidamide group, where the heterocyclic group is a 5-membered monocyclic aryl group containing 1-4 heteroatoms of N, O or S, the heterocyclic group is optionally substituted by one or more 1-6C alkyl or polyhalo-1-6C-alkyl group. Independent claims are included for: (1) the preparation of (I); and (2) 3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine-1,1-dioxide compound of formula (V). Hal = halo such as fluorine, chlorine or bromine. [Image] [Image] ACTIVITY : Nootropic; Tranquilizer; Antidepressant; Neuroprotective; Antiparkinsonian; Cerebroprotective; Anticonvulsant; Antialcoholic; Neuroleptic; Vasotropic. MECHANISM OF ACTION : Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulator. Tests details are described but no results given.