THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

PURPOSE: A thiazole derivative which is effective as a SGLT2(sodium-dependant glucose cotransporter) inhibitor is provided to prevent and/or treat metabolic disorder, especially diabetes. CONSTITUTION: A compound, a pharmaceutically acceptable salt thereof, or precursor drug thereof is denoted by ch...

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Main Authors KIM, JEONG MIN, LEE, JUN WON, KIM, MIN JU, LEE, SUNG HAN, LEE, JIN HWA, KIM, JONG YUP, SEO, HEE JEONG, SONG, KWANG SEOP, SON, EUN JUNG, KONG, YOUNG GYU, LEE, SUK HO, PARK, EUN JUNG, KANG, SUK YOUN
Format Patent
LanguageEnglish
Korean
Published 28.03.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PURPOSE: A thiazole derivative which is effective as a SGLT2(sodium-dependant glucose cotransporter) inhibitor is provided to prevent and/or treat metabolic disorder, especially diabetes. CONSTITUTION: A compound, a pharmaceutically acceptable salt thereof, or precursor drug thereof is denoted by chemical formula I. In chemical formula I, ring A is benzene, naphthalene, or indole; ring B is thiazole; X is methyl or cyclopropyl; Y is H or C1-4 alkoxy or forms 3-7-membered heterocyclic alkyl or 3-7-membered heteroaryl by being fused with a substituent of ring A; and Z is methylene or cyclopropane.
Bibliography:Application Number: KR20137001486